E3 UBIQUITIN LIGASE MARCH5 POSITIVELY REGULATES JAPANESE ENCEPHALITIS VIRUS INFECTION BY CATALYZING THE K27-LINKED POLYUBIQUITINATION OF VIRAL E PROTEIN AND INHIBITING MAVS-MEDIATED TYPE I INTERFERON PRODUCTION

ABSTRACT Membrane-associated RING-CH-type finger (MARCH) proteins, a class of E3 ubiquitin ligases, have been reported to be involved in the infection of multiple viruses and the regulation of type I interferon (IFN) production.However, the specific role and mechanisms by which MARCH proteins influence Japanese encephalitis virus (JEV) infection re

Introduction: With the development and widely use of HER2 targeted therapies, HER2 expressing metastatic breast cancer have no longer dismal prognosis as once expected.The combination of HER2 targeted therapies with chemotherapatic agents prolongs overall survival.Pertuzumab is a new monoclonal antibody molecule that binds to the extracellular port

Fabrizio Cantini1, Laura Niccoli1, Carlotta Nannini1, Olga Kaloudi1, Emanuele Cassarà1, Massimo Susini2, Ivo Lenzetti21Second Division of Internal Undercounter Freezers Medicine, Rheumatology Unit, 2Division of Ophthalmology, Prato Hospital, Prato, ItalyPurpose: To evaluate the long-term efficacy of infliximab in patients with refractory

For the classification task, neural network-based approaches attempt to distinguish between two distributions by determining the joint distribution of input variables for each class.However, the most challenging task is still to classify the observations in the overlapping region Perennials of two classes.In this work, we propose a new discriminati

The motion of a free falling object and a simple pendulum were analyzed by digital cameras and computer programs (Sony Vegas, Adobe Photoshop and Microsoft Excel).The positions of the moving objects were evaluated every 33 Curling - Accessories - Miscellaneous ms from a series of images and experimental results were compared with fundamental equati